SERPINE1 and Behcet disease: In addition, subsequent dysregulation in thrombogenesis and fibrinolysis, subsequently, a multifactorial process related to fibrinolysis including secretion of endothelial-derived proteins [i.e., plasminogen activator inhibitor 1 (PAI1)], tissue factor exposure, and inherent dysregulation in plasma homocysteine levels may contribute together to vascular involvement in BD (Figure 1) (55, 56).