Recent genomic profiling studies have defined SCLC molecular subtypes based on the relative expression of key transcription regulators, including ASCL1, NeuroD1 (neurogenic differentiation factor 1), YAP1 (yes-associated protein 1), and POU2F3 (POU domain class 2 homeobox 3). This evidence concerns the gene YAP1 and small cell lung carcinoma.