IGHE and allergic disease: We found that the levels of PTX3 were positively correlated with the levels of IgE in the serum from shrimp extract- (Spearman′s correlation  = 0.8601 and p  = 0.0003) or tropomyosin peptide-sensitized (Spearman′s correlation  = 0.7972 and p  = 0.0019) mice (Figure 4(c) and Supplementary Figure 1), suggesting that PTX3 may be involved in IgE-mediated allergic reaction.