The frequency of CCT haplotype of HSP70-1 (rs1008438-rs562047-rs12190359) was significantly lower in PSS patients than those in healthy controls (Table 3), suggesting that individuals carrying CCT haplotype of HSP70-1 (rs1008438-rs562047-rs12190359) might decrease the risk of PSS. This evidence concerns the gene HSPA1B and peeling skin syndrome.