INS and Insulin resistance: On the other hand, elevated plasma free fatty acids due to the elevation in the lipolytic rate (high HSL activity) could damage lipid profiles by improving the‏ production of very-low-density lipoprotein (VLDL) by the liver, pushing toward dyslipidemia [12, 13], decrease insulin sensitivity in the tissue, and cause insulin resistance development, type 2 diabetes, and other metabolic abnormalities [14].