The Wnt/β-catenin and PI3K/AKT signaling pathway are involved in a wide range of biological processes, including cell migration, proliferation, differentiation, apoptosis, and immune response.78, 79The alteration of these signaling pathways is a major cause of carcinogenesis.Fusobacterium nucleatumcan activate the Wnt/β-catenin pathway through the upregulation of cyclin-dependent kinase 5 (Cdk5), and promote tumor cell proliferation and migration.80Peptostreptococcus anaerobiuscould drive CRC through increasing the gene expression and protein level of PI3K and AKT.81 The gene discussed is AKT1; the disease is neoplasm.