Changes in KAT5 gene expression has been correlated with cancer progression (Ahmad et al., 2021; Feng et al., 2014; Kim and Lee, 2019; McGuire et al., 2019; Tan et al., 2020; Wei et al., 2019; Yoshida et al., 2011) and small molecule inhibitors targeting KAT5 have already been developed (Brown et al., 2016; Coffey et al., 2012; Cregan et al., 2016; Ghizzoni et al., 2012; Wang et al., 2019). This evidence concerns the gene KAT5 and cancer.