Hypertensive induced myocardial fibrosis was also studied under the effect of 1D11 in vivo and in vitro treatment (Wong et al., 2018), where it was shown that connective tissue growth factor (CTGF) expression is dependent on TGF-β signaling in a model of myocardial fibrosis. The gene discussed is TGFB1; the disease is Myocardial fibrosis.