We tested associations of total 25‐hydroxyvitamin D (25[OH]D), the ratio of 24,25‐dihydroxyvitamin D3 to 25‐hydroxyvitamin D3 (vitamin D metabolite ratio, VDMR), parathyroid hormone (PTH), and fibroblast growth factor‐23 (FGF‐23) concentrations measured in serum with risk of hip and vertebral fractures in the Multi‐Ethnic Study of Atherosclerosis (MESA). This evidence concerns the gene FGF23 and bone fracture.