Nephrologists commonly use PTH as a biomarker of bone turnover in chronic kidney disease (CKD), and studies consistently show associations between PTH and fractures in patients with CKD.(48, 49, 50, 51) Studies examining the relationship between PTH and fractures in populations with normal kidney function are much more sparse, and those that have examined the PTH–bone relationship have largely used BMD as an outcome. This evidence concerns the gene PTH and chronic kidney disease.