GCK and type 2 diabetes mellitus: We identified three genes previously reported by a recent analysis of the UKBB (GCK, HNF1A, and GIGYF1),14 provided stronger evidence for a previously nominally associated gene (TNRC6B),11 and identified three new genes (ZEB2, MLXIPL, and IGF1R) where rare variants increase susceptibility to T2D (Figure 2).