GIGYF1 and type 2 diabetes mellitus: We confirmed the T2D associations at all three genes identified by three previous studies of T2D risk that incorporated European genetic ancestry individuals from the UKBB study:11,12,14GCK (n = 35 carriers; odds ratio [OR] = 58.5 [95% confidence interval (CI) = 25.5–134.5]; p = 2.0 × 10−58), HNF1A (n = 33; OR = 12.7 [6.2–25.8]; p = 4.4 × 10−20), and GIGYF1 (n = 133; OR = 4.7 [3.1–7.0]; p = 4.4 × 10−16; Figure 2).