,7,8 Initial exome-wide association analyses of these data have identified gene-based associations with increased risk of T2D for GCK, HNF1A, HNF4A, GIGYF1, CCAR2, TNRC6B, and PAM and protective effects for variants in FAM234A and MAP3K15.5,9,10,11,12,13,14. The gene discussed is GIGYF1; the disease is type 2 diabetes mellitus.