,7,8 Initial exome-wide association analyses of these data have identified gene-based associations with increased risk of T2D for GCK, HNF1A, HNF4A, GIGYF1, CCAR2, TNRC6B, and PAM and protective effects for variants in FAM234A and MAP3K15.5,9,10,11,12,13,14. This evidence concerns the gene GCK and type 2 diabetes mellitus.