Carriers of qualifying variants within the IGF1R protein kinase (residues 999–1274)25 had a higher risk for T2D (n = 179; OR = 3.4 [2.3–4.9]; p = 1.9 × 10−10) than those with qualifying variants outside this domain (n = 215; OR = 1.7 [1.2–2.6]; p = 8.2 × 10−3). Here, IGF1R is linked to type 2 diabetes mellitus.