TNRC6B and type 2 diabetes mellitus: Finally, we also found that TNRC6B PTV carriers had elevated HbA1c levels when considering both T2D cases (4.1 mmol/mol [2.5–5.7]; p = 7.2 × 10−7; Figure S3) and controls (1.6 mmol/mol [0.2–2.1]; p = 1.8 × 10−2), consistent with the elevated long-term blood glucose levels observed in individuals with T2D.