We also identified three additional genes that, when disrupted by rare genetic variation (minor allele frequency <0.1% or singletons), are associated with increased T2D risk: IGF1R (n = 394; OR = 2.4 [1.8–3.2]; p = 1.3 × 10−10), MLXIPL (n = 245; OR = 2.3 [1.6–3.2]; p = 3.2 × 10−7), and ZEB2 (n = 31; OR = 5.5 [2.5–12.0]; p = 6.4 × 10−7; Figure 1). The gene discussed is IGF1R; the disease is type 2 diabetes mellitus.