Microglia phagocytose large amounts of oxidized lipids and myelin debris in response to neural injury at the beginning of the disease, but as more lipids are phagocytosed, secondary cytotoxic effects are caused, and hyperlipidemia can upregulate CD36 expression and exacerbate ischemic brain injury by promoting CD36-mediated inflammation [73]. The gene discussed is CD36; the disease is hyperlipidemia.