GFAP and Alzheimer disease: 3-D reconstruction images reveal the morphological differences between cortical astrocytes in Non-AD and AD-like aged degus (Fig. 10i), and quantification shows increases in cell volumes for both GFAP-labeled astrocytes and IBA-1-positive microglia in both somatosensory cortex and hippocampus of the AD-like degus compared to age-matched Non-AD degus (Fig. 10j, k).