05); the positive rate of BPTF in lung adenocarcinoma was 52%, and the para-cancer positive rate was 3.2%, the difference was statistically significant (P < 0.05). According to Pearson Chi-square test analysis, BPTF overexpression and VEGF overexpression were statistically significant with lymph node metastasis and clinical stage, respectively, while there was no significant correlation with patient age, gender and tumor size. Here, VEGFA is linked to metastatic malignant neoplasm in the lymph nodes.