This study aimed to clarify the regulation of VEGF expression by BPTF in non-small cell lung cancer, the correlation between the expression of BPTF and clinicopathological parameters and patient prognosis, and the relationship between the expression of BPTF and the efficacy of bevacizumab treatment. Therefore, all the results could provide a theoretical and experimental basis for further revealing the biological functions and the related molecular mechanisms of BPTF in cancer, especially in lung cancer. This evidence concerns the gene BPTF and lung cancer.