The ISIS-AENET model identified 182 DMPs as associated with fasting glucose (Additional file 2: Table S1) and 182 DMPs as associated with HOMA-IR (Additional file 2: Table S2), with an overlap of six DMPs annotated to the genes MRPS31 (associated with type 1 diabetes in previous studies), SH2B1 (associated with severe obesity and insulin resistance), ABCG1 (associated with type 2 diabetes), ABHD11 (involved in weight gain regulation), PSMF1 (control of proteasome function) and HMGN1 (associated with the process of transcriptionally active chromatin). The gene discussed is SH2B1; the disease is obesity due to melanocortin 4 receptor deficiency.