The ISIS-AENET model identified 182 DMPs as associated with fasting glucose (Additional file 2: Table S1) and 182 DMPs as associated with HOMA-IR (Additional file 2: Table S2), with an overlap of six DMPs annotated to the genes MRPS31 (associated with type 1 diabetes in previous studies), SH2B1 (associated with severe obesity and insulin resistance), ABCG1 (associated with type 2 diabetes), ABHD11 (involved in weight gain regulation), PSMF1 (control of proteasome function) and HMGN1 (associated with the process of transcriptionally active chromatin). This evidence concerns the gene HMGN1 and obesity due to melanocortin 4 receptor deficiency.