For example, LDL-C has been shown to have a lower predictive value for CVD development among individuals with obesity or metabolic syndrome who present with low HDL-C levels, fasting and postprandial hypertriglyceridemia, elevated small and dense apo B lipoproteins, and thus a high residual CVD risk [4]. Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.