Similarly, treatment with Silybin, another PPARα agonist, effectively alleviates the symptom of NAFLD in the clinic by reducing fat mass and inducing CPT-1 and MCAD expression [37]. Interestingly, treatment with CLP also enhanced the expression of hepatic PPARα, CPT-1 and MCAD in the HFD-fed mice, which may contribute to its beneficial effect on NAFLD. Here, PPARA is linked to metabolic dysfunction-associated steatotic liver disease.