The tops KEGG pathways in upregulated mRNAs comprised systemic lupus erythematosus, viral carcinogenesis, mitogen-activated protein kinase (MAPK) signaling pathway, hepatitis B, HTLV-1 infection, inflammatory bowel disease, rheumatoid arthritis, osteoclast differentiation (Fig. 2c, d). The gene discussed is WNK2; the disease is rheumatoid arthritis.