HMGB2 and cancer: The results revealed that the cancer cell subclusters c8_TOP2A, c9_HMGB2, c12_MKI67, and c13_TK1 were dominantly in a cycling state, while c1_TCN1, c2_CD74, c3_CD24, c5_CEACAM6, and c10_SAT1 were mainly in a quiescent state (Figure 3g,h).