According to previous studies, LAMP3+ tDCs are enriched in tumor tissues and can inhibit the activation of CD8+ T cells by recruiting Treg cells and other CCR4+ immune cells to tumor regions.[41] Another immunosuppressive cluster of myeloid cells, CCL18+ M2‐like macrophages, are more likely to exist in the metastatic microenvironment due to hypoxia induction and metabolic reprogramming.[42] It is well established that cancer‐associated fibroblasts remodel the extracellular matrix and promote cancer immune evasion in the tumor microenvironment. This evidence concerns the gene CCR4 and neoplasm.