We have recently identified Rab22a‐NeoF1 fusion protein as promoting osteosarcoma lung metastasis,[5, 6] and in this report we identified that Rab22a‐NeoF1 fusion protein was degraded by STUB1 E3 ligase, also known as carboxyl terminus of hsc70‐interacting protein (CHIP),[21] which may function as a tumor suppressor in osteosarcoma. The gene discussed is RAB22A; the disease is neoplasm.