More importantly, by two screenings of the kinase library and kinase inhibitors library, we discovered that Sorafenib and Regorafenib as multi‐kinase inhibitors diminished osteosarcoma lung metastasis induced by Rab22a‐NeoF1 fusion protein via the PINK1/Rab22a‐NeoF1 axis. The gene discussed is RAB22A; the disease is osteosarcoma.