The ratio of α-cell mass to β-cells mass was ∼40% higher in pancreatic islets in SCD1−/− chow-fed animals compared with WT chow-fed animals and ∼35% higher in pancreatic islets in SCD1−/− HF diet-fed animals compared with WT HF diet-fed animals (Figure 5D). The gene discussed is SCD; the disease is hydrops fetalis.