ESR1 and breast adenocarcinoma: As shown in Figure 6, C–E, TSP1 domain of CCN5 induced robust increase of ER-α mRNA levels as well as of mRNA levels of the differentiation markers E-cadherin and ID2 in MDA-MB-231 cells, indicating that the TSP1 domain of CCN5 may promote differentiation of mammary adenocarcinoma cells towards a less aggressive and invasive phenotype by inhibiting EMT and inducing responsiveness to estrogens.