Indeed, several of the cargo recognized by Kapβ2 are prominent RNA-binding proteins (RBPs) with prion-like domains (PrLDs), which are connected to neurodegenerative disease via both pathology and genetics, including FUS, hnRNPA1, hnRNPA2, TAF15, and EWSR1 (8, 10, 11, 15, 16, 29, 30, 31, 32, 33, 34). The gene discussed is HNRNPA1; the disease is neurodegenerative disease.