Our yeast model of FUS proteinopathy has illuminated several genetic modifiers of FUS aggregation and toxicity, which have translated to fly, mammalian cell, and neuronal models of ALS/FTD (16, 18, 92, 93, 94, 97, 98, 99, 100, 101, 102). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.