It has been found that AMP‐activated protein kinase (AMPK) plays an important role in regulating cell proliferation and apoptosis, and activation of AMPK can inhibit cardiac hypertrophy (Gélinas et al., 2018), and GLP‐1 can inhibit vascular smooth muscle cell proliferation through activation of AMPK (Jojima et al., 2017). The gene discussed is GLP1R; the disease is cardiac hypertrophy.