It has been found that AMPK also plays an important role in regulating cell proliferation and apoptosis, and activation of AMPK can inhibit cardiac hypertrophy (Gélinas et al., 2018), and GLP‐1 can inhibit vascular smooth muscle cell proliferation through activation of AMPK (Jojima et al., 2017). Here, GLP1R is linked to cardiac hypertrophy.