Collectively, this study shows that CB‐GLP‐1 treatment of hypertension is mediated by the expression of GLP‐1 and secretion of butyric acid to regulate the RAAS system and GPR109A in the kidney and that CB‐GLP‐1 activates the AMPK signalling pathway to regulate myocardial proliferation and apoptosis and ameliorate cardiomyocyte hypertrophy and ventricular wall fibrosis, in addition, CB‐GLP‐1 treatment through the host bacterial CB increased the abundance and biodiversity of probiotic bacteria, transforming the hypertension‐affected microbial ecology to normal levels (Figure 6). The gene discussed is HCAR2; the disease is hypertensive disorder.