In the present study, a total of 14 immune checkpoint genes (PDCD1 (PD-1), CD274 (PD-L1), CTLA4, ADORA2A, C10orf54 (VISTA), HAVCR2 (TIM-3), ICOSLG, NT5E, CD27, IDO2, LAG3, TIGIT, TNFRSF18, and TNFRSF9) and nine m6A regulators (METTL14, WTAP, FTO, ALKBH5, YTHDF1, YTHDF2, YTHDF3, YTHDC1, and YTHDC2) were differentially expressed between the two groups of patients with ccRCC. This evidence concerns the gene TIGIT and nonpapillary renal cell carcinoma.