CD4 and osteogenesis imperfecta: In multivariable analysis adjusted for age, sex, time-updated CD4 count, present OI, weight at first-line failure and adherence, (a) CD4 count level ≤ 350 cells/mm3 [adjusted OR (aOR), for 200–350 cells/mm3: 3.39; 95% CI, 1.63–7.05), and aOR for CD4 count < 200 cells/mm3: 4.15; 95% CI, 1.98–8.71], (b) present OI (aOR 4.84; 95% CI 1.77–13.24) and (c) weight < 51 kg at first-line failure (aOR 2.67; 95% CI 1.33–5.34) remained significantly associated with VF (Table 2).