In the present study, inspired by the endogenous repair response of tubule-derived VEGF-A + sEV, we developed sEV overexpressing recombinant VEGF-A by engineering TECs and demonstrated a proof of concept: hijacking exogenous sEV as a nanocarrier to deliver VEGF-A to the kidney, which efficiently restored PTC density, reduced renal inflammation and fibrosis, and ultimately blocked AKI-to-CKD transition. This evidence concerns the gene VEGFA and chronic kidney disease.