Furthermore, we examined the effect of Slc7a3 depletion on the development of the hematological malignancy induced by a gain-of-function mutation in Ptpn11 (Ptpn11E76K/+) identified in juvenile myelomonocytic leukemia (JMML)23. This evidence concerns the gene PTPN11 and juvenile myelomonocytic leukemia.