Meantime, each TIME marker was associated with different clinicopathologic features: CD3 was significantly lower in IDC cases (OR 0.43, 95% CI 0.22–0.83, P = 0.012); CD4 was positively correlated with tumor size (≥  2 cm vs < 2 cm, OR 1.79, 95% CI 1.11–2.88, P = 0.017) and grade (I vs III, OR 0.40, 95% CI 0.16–0.99, P = 0.047); premenopausal (vs postmenopausal, OR 1.59, 95% CI 1.05–2.44, P = 0.028) and RS > 25 (vs ≤ 25, OR 1.66, 95% CI 1.10–2.50, P = 0.016) were independent predictors for higher CD8. This evidence concerns the gene CD4 and neoplasm.