RAN and gastric cancer: Upon treatment with the protein synthesis inhibitor cycloheximide (CHX), HGC27 and MKN74 cells with LINC00858 knockdown exhibited a shorter RAN half-life than the control cells (Fig. 4F and Additional file 1: Fig. S3B), indicating that LINC00858 might inhibit the proteasome-dependent degradation of RAN in GC.