D. Bhaskar Rao et al. showed that knockdown of YY1 in gastric cancer cells resulted in inhibition of the Wnt/β-catenin, JNK/MAPK, ERK/MAPK, and HIF-1α signaling pathways [37], all of which have been shown to play vital roles in malignant metastasis. This evidence concerns the gene MAPK8 and gastric cancer.