Proteins interacting with LINC00858 were identified via mass spectrometry, of which only three proteins, ARG1, RAN and HNRNPD were annotated to be related to tumor metastasis in the Human Cancer Metastasis Database (HCMDB), and according to the emPAI, RAN ranks first (Additional file 1: Table S3) and was therefore selected for following assays. The gene discussed is RAN; the disease is neoplasm.