Further, increased VLCFA levels in X-ALD macrophages altered the expression of molecules associated with extracellular matrix remodelling (CXCL5, PLAUR and hyaluronidase1, HYAL1) and formation of membrane protrusions, as well as the modulation of BBB integrity for immune cell infiltration (CXCL8). The gene discussed is CXCL8; the disease is X-linked adrenoleukodystrophy.