Further, increased VLCFA levels in X-ALD macrophages altered the expression of molecules associated with extracellular matrix remodelling (CXCL5, PLAUR and hyaluronidase1, HYAL1) and formation of membrane protrusions, as well as the modulation of BBB integrity for immune cell infiltration (CXCL8). This evidence concerns the gene HYAL1 and X-linked adrenoleukodystrophy.