Although many proinflammatory cytokines such as interleukin (IL)-1β, IL6, tumor necrosis factor-alpha(TNF-α), IL-8, etc., were found to be significantly increased in HS patients in the early years [23–25], the research on the pathogenesis of excessive inflammation in HS has not been elucidated. This evidence concerns the gene IL1B and histiocytic sarcoma.