Although the PPI network resulted in the report of related human genes with structural genes of SARS-CoV-2, the exact effects of ZDHHC5 and GOLGA7 on S protein of SARS-CoV-2, the mechanism of interaction between N protein and SG disassembly, and the exact role of AKAP8L in viral infection and its mechanism are unclear. This evidence concerns the gene AKAP8L and viral infectious disease.