INS and type 2 diabetes mellitus: For rs3765467, Korean patients with T2DM carrying mutant allele A (GA/AA) showed a significantly better hypoglycemic effect to DPP-4 inhibitors than those with genotype GG [47], indicating that mutant genotype GA/AA could improve the function of GLP-1R mediating insulin secretion, while the major genotype GG might be a risk factor for disease.