Similarly, Jiang et al. in 2017 found that obese PCOS patients who were treated with CC had a higher LH level on HCG day [10], and the reason for this can be explained as there were some gene mutations of the LH and LH receptors in women with PCOS that made them LH-dependent during follicle development [20]. Here, PLOD1 is linked to polycystic ovary syndrome.