As for their localization, the brain constitutes the most common distant metastatic site in LADC patients, followed by the bones.19, 20, 21 Notably, the incidence of brain metastasis (BM) can rise up to 50%-60% in patients harboring EGFR or ALK rearrangements over the course of their disease.22, 23, 24 Although cellular and molecular mechanisms underlying tumor progression have been extensively investigated in the past decade,9,25 early metastases represent a major barrier of therapeutic success. Here, EGFR is linked to neoplasm.