Of these, the YBX1 protein, which has been associated with poor prognosis and early metastasis in renal cell and hepatocellular carcinoma41 is noteworthy, together with the ribosomal proteins previously related to tumor development and other associated processes.37, 38, 39, 40 Additionally, histological examination showed that BMs exhibit a higher intratumoral vascularization, which is known to be a hallmark of the BM cascade.55 This evidence concerns the gene YBX1 and neoplasm.