These included a number of pro-metastatic gene products, such as COMP, TF, SFRP2, POSTN, CAV1, S100A4, LGALS1, COL6A1, CTSZ and HMGB1 overexpressed in primary tumors, and RAC1, SRC, YBX1, CSNK2A2, ENAH and GOLM1 overexpressed in metastatic tumor samples.41 This evidence concerns the gene HMGB1 and metastatic neoplasm.