INS and metastatic neoplasm: In comparison, pathways related to metabolism (e.g. oxidative phosphorylation, arginine and proline metabolism, insulin secretion and valine, leucine and isoleucine degradation), translation (e.g. messenger RNA (mRNA) surveillance and RNA transport) or vesicle formation (e.g. SNARE interactions in vesicular transport) were overrepresented in metastatic tumors.