BDNF and mood disorder: A set of targets related to oxidative stress, neurotrophins, and inflammation as key mediators of the cognitive and general health impairments that occur with recurrent mood episodes were reported for the first time en bloc on a systemic toxicity index (STI).53 The same STI was evaluated in early-stage mood disorders and use of medications was associated with significantly lower toxicity.54 In the present study, the mood stabilizer lithium and the antipsychotic clozapine were associated with lower levels of HSP70 in BD and SCZ groups, respectively.