ANKRD22 and colorectal cancer: As for homo sapiens ankyrin repeat domain 22 (ANKRD22), which encoded a specific mitochondrial protein, it has been demonstrated to be involved in the progression of multiple tumors, including colorectal cancer [30], breast cancer [31], pancreatic cancer [32], prostate cancer [33], and nonsmall-cell lung cancer [34]; however, there are few relevant studies on sepsis and further investigation is required.