In fact, the LHb has been implicated in coding of negative emotions (Matsumoto and Hikosaka, 2007; Shabel et al., 2012) and is aberrantly hyperactive in individuals with depression (Li et al., 2011, 2013; Morris et al., 1999; Shumake and Gonzalez-Lima, 2003). Here, LHB is linked to major depressive disorder.