Interestingly, we could detect a DMR in the gene PRDM16 (Fig. 4c), a gene shown to be involved in cardiomyopathy [55], which was consistent with the symptoms experienced by the patients (i.e., GEO ID: GSM2366439, GSM2366759, GSM2366459, GSM2366724). Here, PRDM16 is linked to cardiomyopathy.