Additional exploratory outcomes included adherence to intervention, group difference in the change from baseline in C-reactive protein (CRP) levels as a marker of systemic inflammation, adverse event rate, incidence of laboratory-confirmed COVID-19 infection, and change from baseline in immunoglobulin G (IgG) SARS-CoV2 serology conversion in those who received COVID-19 vaccination during the trial. The gene discussed is CRP; the disease is COVID-19.