TMA immunohistochemical data also revealed a negative correlation between SPTBN1 and GPT2 (NJMU ccRCC TMA cohort2: N = 180; Pearson: R = − 0.274, P < 0.001; Spearman: R = − 0.292, P < 0.001; Fig. 5F, G). This evidence concerns the gene SPTBN1 and nonpapillary renal cell carcinoma.