SPTBN1 and nonpapillary renal cell carcinoma: In univariate and multivariate cox regression analyses, SPTBN1 served as an independent predictive factor for the survival of ccRCC patients (Univariate: HR = 0.532, 95% CI = 0.444 − 0.637, P < 0.001; Multivariate: HR = 0.647, 95% CI = 0.489–0.854, P = 0.002; Fig. 2B).