The flowchart of screening process was illustrated in Fig. 1A. Our results confirmed that SPTA1 and SPTBN5 were up-regulated in ccRCC tissues, while SPTAN1, SPTB, SPTBN1, SPTBN2, and SPTBN4 were down-regulated in ccRCC tissues (Fig. 1B, C). The gene discussed is SPTBN4; the disease is nonpapillary renal cell carcinoma.