SPTBN1 and nonpapillary renal cell carcinoma: In accordance with the findings in TCGA and GEO datasets, SPTBN1 expression was significantly down-regulated in ccRCC cell lines (786-O, 769-P, ACHN, and Caki-1) at both mRNA and protein levels, compared with that in renal tubular normal epithelial cell line HK-2 (P < 0.05; Fig. 1L).