Considering that VEGF/VEGFR, PDGF/PDGFR related signal pathways play essential roles during the development of T2D, such as insulin resistance [49], the expression of iron metabolism related-proteins [50], islet cell inflammation [51], further studies to investigate potential therapeutic benefits for sunitinib in T2D are warranted. The gene discussed is KDR; the disease is type 2 diabetes mellitus.