Further verification, we discovered that NFKB1 is highly expressed in the T2D group (Fig. 5B) (the expression value of RFXANK, RFXAP, RFX5, CIITA, ILF3, and RELA1 missing in proteomics data from obese diabetic mice), which coordinately participated in the regulation of four hub genes (IRF7, PSMB9, CD74, and COL1A1). Here, RFXAP is linked to type 2 diabetes mellitus.