The overall survival of nude mice was prolonged correspondingly in comparison to mice bearing tumor xenografts upregulated with MDHDH and this could be reversed by PSMA1 knockdown (NC vs. MDHDH: Log-rank P=0.0006, NC vs. OE MDHDH+shPSMA1: no significance Fig. 6D, bottom). This evidence concerns the gene PSMA1 and neoplasm.