Overexpression of MDHDH significantly reduced the ECAR and OCR levels in glioma cells, and the ECAR and OCR levels in the cell model after overexpression of MDHDH and knockdown of PSMA1 were close to those in the control group (ECAR: U87 NC vs. OE: P= 0,0072 NC vs. OE+siPSMA1: no significance U251 NC vs. OE: P= 0.0031 NC vs. OE+siPSMA1: no significance OCR U87 NC vs. OE: P= 0.0002 NC vs. OE+siPSMA1: no significance U251 NC vs. OE: P= 0.0009 NC vs. OE+siPSMA1: no significance) (Fig. 5F). This evidence concerns the gene LINC00632 and central nervous system cancer.