To elucidate the functions of MDHDH in gliomas, we transfected both U87 and U251 glioma cells with plasmids expressing MDHDH (pcDNA3.1, OE MDHDH, Supplementary Figure S3A) or MDHDH Smart Silencer (siMDHDH). The gene discussed is LINC00632; the disease is central nervous system cancer.