The results confirm that the tumor formation derived from MDHDH-overexpressing U87 cells was significantly suppressed (Total flux 7d NC vs. MDHDH:P=0.0031; 14d NC vs. MDHDH:P=0.0033), and overexpression of MDHDH prolonged the survival time of the experimental animals (NC vs. MDHDH: log-rank P=0.0018) (Fig. 2E). The gene discussed is LINC00632; the disease is neoplasm.