Regarding the intracranial tumor xenografts in nude mouse models derived from U87 cells, PSMA1 silencing significantly abolished the suppressive role of MDHDH in the tumor xenograft growth level (Total flux: 7d NC vs. OE: P<0.0001, NC vs. OE+shPSMA1: no significance; 14d NC vs. OE: P=0.0204, NC vs. OE+shPSMA1: no significance; Fig. 6D and F). The gene discussed is PSMA1; the disease is neoplasm.