POLG and Encephalopathy: In FIRES patients, genes associated with fever-sensitive epilepsy as sodium voltage-gated channel protein type 1 subunit alpha (SCN1A), DNA polymerase subunit gamma- 1 (POLG) and protocaldherin-19 (PCDH19) were analyzed and no mutations were reported [19] as well no mutations were found in genes associated with infection-triggered encephalopathy and SE.