The European Alpha-1 antitrypsin Deficiency Research Collaboration (EARCO) international registry is an initiative of the EARCO Clinical Research Collaboration (CRC) of the ERS, with the objective of characterising AATD of different genotypes and investigating their natural history and the impact of different treatments, including augmentation therapy [13, 14]. Here, SERPINA1 is linked to alpha 1-antitrypsin deficiency.