PCSK9 and Insulin resistance: In support, plasma PCSK9 levels in IT-DIAB (233 patients with prediabetes, follow-up 5 years) and the ELSA-Brasil (1,751 patients, 27.5% with prediabetes, follow-up 4 years) were not significantly associated with new-onset diabetes or glucose homeostasis, except for a positive correlation with insulin resistance in ELSA-Brasil [58].