We analyzed the regulatory relationships associated with the expression of 39 cell senescence-associated genes in GBM patients, for example, EZH2 positively regulates PTTG1 expression, while PTTG1 has a significant positive effect on TACC3 expression, and the result is presented in Fig. 2A. In the meantime, to deepen our understanding, we researched the somatic mutation prevalence of cell senescence-associated genes among GBM. This evidence concerns the gene PTTG1 and glioblastoma.