IGFBP3 and glioblastoma: In an exploration of the effect of 39 cell senescence-associated genes on the overall survival (OS) of GBM patients, we found that downregulation of MYC, LIMA1 and SIX1 expression and upregulation of PTTG1, EZH2, AURKA, TACC3, VEGFA, CENPA, IGFBP3 and SOCS1 expression exhibited a statistically significant effect on the overall survival of GBM patients (Fig. 2E).