Afterwards, the HRs (95% CIs) of the populations carrying SNP with certain function in cancer risk were pooled and calculated to be 1.42 (1.16, 1.68) (Fig. 2B), demonstrating that the polymorphisms of CYP24A1 which were correlated to cancer risk were positively associated with poorer prognosis. The gene discussed is CYP24A1; the disease is cancer.