STAT1 and immunodeficiency disease: The most frequently reported monogenic immunodeficiency disease that causes IC and CNSC is Caspase Recruitment Domain Family Member 9 (CARD9) defects, followed by Autoimmune Regulator (AIRE), Signal Transducer And Activator Of Transcription 1 (STAT1), STAT3, and Interleukin 17F (IL17F) defects [6–8].