ROCK1 and viral infectious disease: These findings are in line with a recent large time-course phosphoproteomics study of SARS-CoV-2 infection in Vero E6 cells (cells highly susceptible to SARS-CoV-2 infection), which described that the viral infection promotes the host’s p38-MAPK cascade while shutting down key mitotic kinases, including phosphoinositide-3-kinase (PI3K), RAC-alpha serine/threonine-protein kinase 1 and 2 (AKT/2), cAMP-dependent protein kinase (PRKACA/B), Rho-associated protein kinase (ROCK1/2) and others [31].